Estibox® RWND Age Defiance Rx is a prescription-only anti-aging cream scientifically formulated with a synergistic blend of Estriol 0.3%, Niacinamide 3%, GHK-Cu peptide 0.2%, and Hyaluronic Acid 0.5% in a 30 g cream base.

This advanced prescription formulation is designed to help improve visible signs of aging by supporting skin elasticity, hydration, and barrier repair.

• Estriol (0.3%): A bio-identical estrogen derivative that supports collagen production and helps improve skin thickness and elasticity.

• Niacinamide (3%): A form of Vitamin B3 that reduces redness, improves skin barrier function, and enhances even skin tone.

• GHK-Cu Peptide (0.2%): A copper-binding peptide known to support tissue regeneration, firming, and smoother skin texture.

• Hyaluronic Acid (0.5%): A hydration powerhouse that helps plump skin and reduce the appearance of fine lines.

Important Safety Information

• For external use only.

• Use as prescribed by a licensed healthcare provider.

• Avoid contact with eyes, mouth, or mucous membranes.

• Possible side effects include mild skin redness, dryness, or irritation.

• Not recommended for patients with known sensitivity to any listed ingredients.

• If irritation persists, discontinue use and consult your prescribing provider.

Packaged in a 30 g prescription cream jar, RWND Age Defiance Rx delivers a dermatologist-formulated approach to skin rejuvenation under physician guidance.

Frequently Asked Questions 

What is Estibox® RWND Age Defiance Rx?
It a prescription anti-aging cream containing Estriol, Niacinamide, GHK-Cu peptide, and Hyaluronic Acid, formulated to improve skin firmness, hydration, and overall texture.

How do I use this cream?
Apply a small, pea-sized amount once daily in the evening to clean, dry skin, or as directed by your healthcare provider. Avoid sensitive areas such as the eyes and lips.

When can I expect to see results?
Most patients notice improved hydration and smoothness within 4–6 weeks, with visible firming and texture refinement typically after 8–12 weeks of consistent use.

Is RWND Age Defiance Rx safe for long-term use?
Yes, under medical supervision. Ingredients like Estriol and GHK-Cu peptide are considered safe in topical concentrations, but long-term use should always be monitored by your prescribing provider.

Can I use this cream with other skincare products?
Yes, but avoid combining with strong exfoliants or retinoids unless directed by your provider, as this may increase irritation. Always apply RWND Age Defiance Rx as the final step in your nighttime skincare routine.

Who should not use this product?
Individuals who are pregnant, breastfeeding, or have hormone-sensitive conditions should consult their healthcare provider before use.